Alcohol and ADH1B and ADH1C gene variant breast cancer

By leayek

A second study, also presented in San Diego, explored another possible mechanism by which alcohol consumption increases breast cancer risk. “For years, we’ve known that there’s an association between alcohol drinking and breast cancer risk, but nobody knows yet what the underlying biological mechanisms are,” said Dr. Catalin Marian, lead author of the study and a research instructor in oncology at the Lombardi Comprehensive Cancer Center at Georgetown University in Washington, D.C. “The logical step was to begin analyzing the alcohol metabolizing genes.”

The researchers studied DNA samples from 991 women with breast cancer and 1,698 women without cancer. They found that variants in two of these genes, ADH1B and ADH1C, were associated with a two-fold increase in breast cancer risk. But the study did not prove a definite cause-and-effect link. “This is an association,” Dr. Marian said. “This type of study is good for generating hypotheses. It’s not a definite conclusion. It needs to be replicated by other studies to say for sure that what we found is there.”

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